Quadris should not be applied as a curative and should be applied prior to the onset of blue mold. If blue mold is present in the field, initiate applications with other control products. Quadris may be applied in the formulation rate range of 6 to 12 floz or 0.1 to 0.2 lbs active ingredient per acre. For Tobacco production, do not apply more than 0.52 lbs active ingredient per acre per season. Do not mix with Thiodan (endosulfan containing products). Tank mixing Quadris with insecticides formulated as ECs or containing high amounts of solvents, may cause some crop injury. Quadris may be applied up to the day of harvest. Quadris may enhance weather flecking on the leaves of certain tobacco types.
http://web.utk.edu/~extepp/whats/wh2006/Issue-9-2006.htm